Sequoiaflavone

Sequoiaflavone is a biflavonoid compound with multiple activities. Sequoiaflavone suppresses hepatic CYP1A1/(7-Ethoxycoumarin O-deethylase) ECOD, prevents Aβ_1-42 fibrillization (IC₅₀ = 0.29 μM) and disaggregates amyloid fibrils (EC₅₀ = 2.04 μM), inhibits Alternaria alternata and inhibits human recombinant PDE5A1 overexpressed in COS-7 cells (IC₅₀ = 19.9 μM) to exert NO-independent vasodilation. Sequoiaflavone can be used in Alzheimer's disease, peripheral circulatory disorder, and antifungal research^[1][2][3][4]. In Vitro:Sequoiaflavone (100 μM; 4 h) fully inhibits spore germination of Alternaria alternata with an ED₅₀ of 18 μM^[1].
Sequoiaflavone (100 μM; 7 h) exerts obvious inhibitory effects on germ tube growth of Fusarium culmorum with an ED₅₀ of 12 μM^[1].
Sequoiaflavone (100 μM; 24 h) shows no detectable antifungal activity against Cladosporium oxysporum ^[1].
Sequoiaflavone (0.08 mg/mL) potently inhibits ECOD activity by 75.2%, leaving just 24.8% residual enzyme activity versus the 100% control level in rat liver microsomes^[2].
Sequoiaflavone inhibits formation of Aβ fibrils with an IC₅₀ of 0.29 μM^[3].
Sequoiaflavone inhibits human recombinant PDE5A1 with an IC₅₀ of 19.9 μM in COS-7 cells^[4].
Sequoiaflavone blocks PDE5A1 activity to slow cGMP degradation in COS-7 cells^[4].
Sequoiaflavone produces vasodilation via a NO-independent pathway in COS-7 cells^[4].