5-O-Demethylnobiletin
CAS No. : 2174-59-6
(Synonyms: 5-Demethylnobiletin)
| Size | Price | Stock |
|---|---|---|
| 1mg | $75 | In-stock |
| 5mg | $158 | In-stock |
| 10mg | $269 | In-stock |
| 20mg | $457 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N1942 |
| M.Wt: | 388.37 |
| Formula: | C20H20O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1]. IC50 & Target:IC50: 0.1 μM (Lox 5); 0.35 μM (LTB4) (5-O-Demethylnobiletin)[1] In Vitro: 5-O-Demethylnobiletin (5-demethylnobiletin) promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[2].
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