PD173212
CAS No. : 217171-01-2
| Size | Price | Stock |
|---|---|---|
| 2mg | $80 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $408 | In-stock |
| 50mg | $612 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-103318 |
| M.Wt: | 599.85 |
| Formula: | C38H53N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays. IC50 & Target: IC50: 36 nM (VSCC)[1] In Vitro: PD173212 (PD 173212, 300 nM) potently blocks recombinant B-class (N-type) calcium channel currents 78±7.8%, with an IC50 of 74 nM, by whole-cell voltage-clamp techniques. PD 173212 possesses selectivity for non L-type Ca2+ channels versus neuronal Na+, K+, and L-type Ca2+ channels[1]. In Vivo: PD173212 (30 mg/kg, i.v.) shows moderate efficacy in preventing tonic seizures in the audiogenic seizure model[1].
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