[Pyr1]-Apelin-13
CAS No. : 217082-60-5
(Synonyms: [pGlu1]-Apelin-13)
| Size | Price | Stock |
|---|---|---|
| 1mg | $110 | In-stock |
| 5mg | $290 | In-stock |
| 10mg | $450 | In-stock |
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| Cat. No. : | HY-P1033 |
| M.Wt: | 1533.80 |
| Formula: | C69H108N22O16S |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist. In Vitro: [Pyr1]-apelin-13 encapsulation in lipoPEG particles (lipoPEG-PA13) results in sustained and extended drug release under physiological conditions[1]. In Vivo: [Pyr1]-apelin-13 nanocarriers in a mouse model of pressure-overload induced heart failure demonstrate a sustainable long-term effect of [Pyr1]-apelin-13 in preventing cardiac dysfunction[1]. [Pyr1] apelin-13 (1, 5 μg) improves locomotor activity and reduces pain symptoms, cavity size and caspase-3 levels in rats. [Pyr1] apelin-13 (1, 5 μg) significantly increases thermal paw withdrawal latency. [Pyr1] apelin-13 in 5 μg dose also produces significant attenuation in paw withdrawal threshold compared to SCI animals from the second week post SCI[2].
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