dTRIM24
CAS No. : 2170695-14-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $159 | In-stock |
| 5mg | $350 | In-stock |
| 10mg | $550 | In-stock |
| 25mg | $1100 | In-stock |
| 50mg | $1760 | In-stock |
| 100mg | $2820 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-111519 |
| M.Wt: | 1113.30 |
| Formula: | C55H68N8O13S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);Methanol : 150 mg/mL (ultrasonic) |
dTRIM24 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24. IC50 & Target:TRIM24[2]. In Vitro: dTRIM24 is a degrader of TRIM24 bromodomain. Recruitment of the VHL E3 ubiquitin ligase by dTRIM24 elicits potent and selective degradation of TRIM24. The anti-proliferative consequences of chemical degradation versus inhibition of TRIM24 are assessed. Growth over time is determined for MOLM-13 cells treated with dTRIM24, IACS-9571, VL-269, and eTRIM24. dTRIM24 suppresses growth to a greater extent than does IACS-9571, accompanied by apoptosis measured as enhanced PARP cleavage. In agreement with a sustained proliferative defect observed following dTRIM24 treatment, near-complete degradation of TRIM24 is observed in dTRIM24-treated cells throughout the duration of the experiment[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- dTRIM24
- Cat. No.:
- HY-111519
- Quantity:
Your information is safe with us.