SOD1-Derlin-1 inhibitor-2


CAS No. : 2170170-27-9

2170170-27-9
Price and Availability of CAS No. : 2170170-27-9
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10mg $80 In-stock
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100mg $366 In-stock
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Cat. No. : HY-123982
M.Wt: 386.47
Formula: C22H18N4OS
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 2170170-27-9 :

SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1]. In Vitro:SOD1-Derlin-1 inhibitor-2 (compound 56-59; 0.1-100 μM) inhibits the SOD1-Derlin-1 interaction in a dose-dependent manner[1]. In Vivo:SOD1-Derlin-1 inhibitor-2 (compound 56-59; i.c.v.; 3 mM, flow rate 0.15 μL/h) ameliorates ALS pathology in ALS model mice[1].

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