Azaribine
CAS No. : 2169-64-4
(Synonyms: 2',3',5'-Tri-O-acetyl-6-azauridine)
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| Cat. No. : | HY-B1537 |
| M.Wt: | 371.30 |
| Formula: | C14H17N3O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba). Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research[1][2].
In Vitro:Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine; 0-2 μM; 48 h) has cytotoxicity on MDCK cells (MTT: CC50=19.66 μM)[1].
Azaribine shows a potent inhibitory effect on BIRFLU multiplication (MDCK cells: EC50=0.29 μM; A549 cells: EC50=0.55 μM)[1].
Azaribine shows against seasonal H1N1 and H3N2 IAVs and IBV during posttreatment in MDCK cells with EC50 of 0.60 μM, 0.77 μM, 0.80 μM[1].
Azaribine is against NC H1N1 during posttreatment in 16HBE cells (EC50=1.58 μM)[1].
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