Fludarabine
CAS No. : 21679-14-1
(Synonyms: F-ara-A; NSC 118218)
| Size | Price | Stock |
|---|---|---|
| 50mg | $12 | In-stock |
| 1g | $46 | In-stock |
| 5g | $158 | In-stock |
| 25g | $398 | In-stock |
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| Cat. No. : | HY-B0069 |
| M.Wt: | 285.24 |
| Formula: | C10H12FN5O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes[1][2][3][4]. In Vitro: Fludarabine (5 μM; 48 hours) induces a decrease in p27kip1 expression[4]. In Vivo: Fludarabine (0.8 mg/kg; i.p.; two cycles for 5 days every 2 weeks) in combination with Cyclophosphamide (400 mg/kg; i.p.; 2 weeks) decreases incidence of GVHD[6].
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