Bz 423
CAS No. : 216691-95-1
(Synonyms: BZ48)
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $155 | In-stock |
| 25mg | $365 | In-stock |
| 50mg | $655 | In-stock |
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| Cat. No. : | HY-13108 |
| M.Wt: | 440.92 |
| Formula: | C27H21ClN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
Bz 423 is a pro-apoptotic 1,4-benzodiazepine with therapeutic properties in murine models of lupus demonstrating selectivity for autoreactive lymphocytes, and activates Bax and Bak. In Vitro: Bz-423 induces a larger superoxide response in Ramos cells, and causes rapid death of Ramos B cells. Bz-423 activates Bax and Bak, but does not activate ASK1/JNK in Ramos cells. In Ramos cells Bz-423-induced superoxide leads to Bax and Bak activation via changes in Mcl-1 expression and functional activation of BH3-only proteins[1]. Bz-423 rapidly increases superoxide levels in MEFs within 1 h and the magnitude of the increase is concentration-dependent. Bz-423-induced apoptosis dependents upon superoxide[2].
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