Alemtuzumab
CAS No. : 216503-57-0
(Synonyms: Campath-IH)
| Size | Price | Stock |
|---|---|---|
| 1mg | $360 | In-stock |
| 5mg | $800 | In-stock |
| 10mg | $1300 | In-stock |
| 25mg | $2600 | In-stock |
| 50mg | $4200 | In-stock |
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| Cat. No. : | HY-P9948 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O |
Alemtuzumab (Campath-IH) is a humanized monoclonal antibody against CD52. Alemtuzumab does not cross-react with murine CD52. Alemtuzumab selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes. Alemtuzumab is capable of complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC), as well as induction of apoptosis. Alemtuzumab has the potential for B-cell chronic lymphocytic leukaemia research[1][2].
In Vivo:Alemtuzumab (Campath-IH; 0.5-5 mg/kg; ip) with a single dose results in the dose-dependent depletion of B and T lymphocytes in the peripheral blood and lymphoid organs[2].
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