H77-77
CAS No. : 21618-99-5
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| Cat. No. : | HY-124331 |
| M.Wt: | 165.24 |
| Formula: | C10H15NO |
| Purity: | >98 % |
| Solubility: |
H77-77 is a selective MAO-A inhibitor with blood-brain barrier permeability, exhibiting an IC50 of 7.4 μM against rat MAO-A. H77-77 accumulates via uptake by serotonergic and noradrenergic neurons. H77-77 releases norepinephrine and serotonin from intracellular neuronal storage sites. H77-77 can be used in studies related to neurological disorders[1]. In Vitro:H77-77 selectively inhibits rat brain mitochondrial MAO-A with an IC50 of 7.4 μM, while no detectable inhibitory effect on MAO-B is observed even at concentrations as high as 500 μM[1]. In Vivo:H77-77 (1.25-10 mg/kg; subcutaneous injection) exerts potent and selective inhibitory effects on monoamine oxidase (MAO) in serotonergic and noradrenergic neurons within the hypothalamus of rats[1].
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