ONO-8711
CAS No. : 216158-34-8
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| Cat. No. : | HY-12182 |
| M.Wt: | 440.00 |
| Formula: | C22H30ClNO4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ONO-8711 is a potent and selective competitive antagonist of EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1 respectively). ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer[1].
IC50 & Target:Ki: 0.6 nM (human EP1), 1.7 nM (mouse EP1)[1]
In Vitro:ONO-8711 (10 and 30 μM; 30 min) blocks the contractions induced by sulprostone in human pulmonary veins in a non-competitive manner[2].
ONO-8711 inhibits PGE2-induced increase in cytosolic Ca2+ concentration with IC50s of 0.21 μM, 0.05 μM, and 0.22 μM for the mouse, human, and rat receptors, respectively[3].
In Vivo:ONO-8711 (400 or 800 p.p.m.; p.o.; for 20 weeks) suppresses cancer incidence and delays occurrence of breast tumors[3].
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