GNE-207
CAS No. : 2158266-58-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $340 | In-stock |
| 10mg | $550 | In-stock |
| 25mg | $1100 | In-stock |
| 50mg | $1750 | In-stock |
| 100mg | $2800 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120028 |
| M.Wt: | 510.59 |
| Formula: | C29H30N6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
GNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP, with an IC50 of 1 nM, exhibits a selectively index of?>2500-fold against BRD4 (1). GNE-207 shows excellent CBP potency, with an EC50 of 18 nM for MYC expression in MV-4-11 cells[1].
IC50 & Target:IC50: 1 nM (CBP)[1], 3.1 μM (BRD4 (1))[1]
In Vitro: GNE-207 is a potent, selective and orally bioavailable inhibitor of the bromodomain of CBP, with an IC50 of 1 nM, a selectively index of?>2500-fold against BRD4 (1) (IC50, 3.1 μM)[1].
GNE-207 shows excellent CBP potency, with an EC50 of 18 nM for MYC expression in MV-4-11 cells[1].
In Vivo: GNE-207 (5?mg/kg) shows moderate clearance in PK, with acceptable oral bioavailability[1].
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