HS-1371
CAS No. : 2158197-70-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $62 | In-stock |
| 5mg | $132 | In-stock |
| 10mg | $209 | In-stock |
| 25mg | $429 | In-stock |
| 50mg | $649 | In-stock |
| 100mg | $979 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114349 |
| M.Wt: | 384.47 |
| Formula: | C24H24N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic) |
HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8?nM[1]. IC50 & Target: IC50: 20.8?nM (RIP3)[1] In Vitro: HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner. HS-1371 has an inhibitory effect on RIP3 kinase activity in various cell lines[1].
HS-1371 (0.1, 1, 5, 10, 20 μM, 9 h) can block RIP3 S227 phosphorylation[1].
HS-1371 (0.1, 1, 5, 10 μM, 24 h) rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death[1].
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