Breceptin
CAS No. : 215713-39-6
(Synonyms: B 9870)
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| Cat. No. : | HY-P1650 |
| M.Wt: | 2815.28 |
| Formula: | C136H200N38O28 |
| Purity: | >98 % |
| Solubility: |
Breceptin (B 9870) is an antagonist of the bradykinin B1/B2 receptor (B1/B2R). Breceptin exhibits an irreversible antagonist effect on B2R, inhibiting the vasodilation induced by Bradykinin (HY-P0206) in the rabbit carotid vein contraction experiment. B-9870 shows partial agonist properties in HEK 293 cells with high expression of B2R, and can activate ERK1/2 phosphorylation, calcium ion mobilization, arachidonic acid release, and receptor internalization. Breceptin can be used in research to inhibit breast cancer and non-small cell lung cancer[1].
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