SU 5402 (GMP)
CAS No. : 215543-92-3
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| Cat. No. : | HY-10407G |
| M.Wt: | 296.32 |
| Formula: | C17H16N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SU 5402 (GMP) is SU 5402 (HY-10407) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGFRβ, respectively[1].
In Vitro:SU 5402 (GMP) (5 μM, added at days 4, 6 and 8 of differentiation) inhibits neural induction from hiPSC as well as hESC (TZ1 hiPSC or H9 hESC), indicating that FGF signaling is required for neural induction[1].
SU 5402 (GMP) (0.8 μM, from day 2 to day 12), together with PD184352 and CHIR99021, enhances the reprogramming efficiency and increases the number of colonies (reprogram MEFs to iPSCs)[2].
SU 5402 (GMP) together with PD184352 and CHIR99021 accelerate differentiation of iPSCs[2].
SU 5402 (GMP) (10 μM, from day 5 to day 17) efficiently differentiates IWR-1 (HY-12238)-treated hiPSCs into retinal pigment epithelium (RPE) progenitors[3].
SU 5402 (GMP) enhances neuronal differentiation efficiency[4].
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