Selpercatinib
CAS No. : 2152628-33-4
(Synonyms: LOXO-292)
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $650 | In-stock |
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| Cat. No. : | HY-114370 |
| M.Wt: | 525.60 |
| Formula: | C29H31N7O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity[1][2].
IC50 & Target:IC50: 14.0 nM (RETWT), 24.1 nM (RETV804M), and 530.7 nM (RETG810R)[2]
In Vivo: Selpercatinib (LOXO-292; 10 mg/kg; i.g.; for 0-2 h) has good pharmacokinetics after oral gavage in FVB/NRj mice[1].
Pharmacokinetic Parameters of Selpercatinib in FVB/NRj mice[1].
| Administration | i.g. (10 mg/kg) |
| Tmax (h) | 1.8 |
| Cmax (ng/mL) | 7862 |
| AUC (ng·h/mL) | 26649 |
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