Rimacalib
CAS No. : 215174-50-8
(Synonyms: SMP 114)
| Size | Price | Stock |
|---|---|---|
| 5mg | $490 | In-stock |
| 10mg | $780 | In-stock |
| 25mg | $1600 | In-stock |
| 50mg | $2500 | In-stock |
| 100mg | $3650 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100779 |
| M.Wt: | 394.44 |
| Formula: | C22H23FN4O2 |
| Purity: | >98 % |
| Solubility: | Ethanol : 16.67 mg/mL (ultrasonic);DMSO : 125 mg/mL (ultrasonic) |
Rimacalib (SMP 114) is a Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor, with IC50s of ~1 μM for CaMKIIα to ~30 μM for CaMKIIγ[1]. IC50 & Target:IC50: ~1 μM (CaMKIIα), ~30 μM (CaMKIIγ)[1]. In Vitro: Rimacalib (SMP-114) improves (by ~40%) Ca2+-transient potentiation during the 30 s stimulation pause, higher Fura-2 transient amplitude after the pause upon Rimacalib vs. 37.2±4.3% in control, n=60/17 cells/mice vs. n=65/17, p<0.05) and in parallel cardiomyocyte contractility (135.0±15.4% vs. 97.2±16% increase of twitch amplitude, p=0.098)[1].
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