Butaprost (free acid)
CAS No. : 215168-33-5
| Size | Price | Stock |
|---|---|---|
| 500μg | $202 | Get quote |
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| Cat. No. : | HY-120973 |
| M.Wt: | 394.54 |
| Formula: | C23H38O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Butaprost free acid is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost free acid is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid attenuates fibrosis by hampering TGF-β/Smad2 signalling[1][2][3].
In Vitro:Butaprost (1-100 nM; 0.5-24 hours) free acid induces about a five-fold upregulation of Nur77 mRNA expression in hEP2-HEK293/EBNA cells in a dose- and time-dependent. Butaprost free acid upregulated Nur77 gene expression through the PKC pathway[1].
Butaprost (50 μM; 24 hours) free acid reduces TGF-β-induced fibronectin (FN) expression, Smad2 phosphorylation and epithelial-mesenchymal transition in Madin-Darby Canine Kidney (MDCK) cells[2].
In Vivo:Butaprost (1-4 mg/kg; intraperitoneal injection; twice daily; for 7 days) free acid treatment attenuates the development of fibrosis in mice that underwent unilateral ureteral obstruction surgery, as illustrated by a reduction in the gene and protein expression of α-smooth muscle actin, fibronectin and collagen 1A1[2].
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