Bruceine D
CAS No. : 21499-66-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $174 | In-stock |
| 10mg | $296 | In-stock |
| 25mg | $592 | In-stock |
| 50mg | $948 | In-stock |
| 100mg | $1422 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N3014 |
| M.Wt: | 410.42 |
| Formula: | C20H26O9 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2]. Bruceine D has strong anthelmintic activity against D. intermedius with an EC50 value of 0.57 mg/L[3].
IC50 & Target: Notch[1]
In Vitro: Bruceine D inhibits the cell viability of H460 and A549 cells in a dose-dependent manner with IC50 values of 0.5 and 0.6 μM, respectively, at 48 h of treatment[1].
Bruceine D (0.125-1.0 μM) dose-dependently promotes chromatin condensation, Annexin V-positive cell population and caspase-dependent apoptosis in H460 and A549 cells[1].
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