Swainsonine (hydrochloride)
CAS No. : 214462-68-7
(Synonyms: GD 003; Tridolgosir hydrochloride)
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| Cat. No. : | HY-N6722A |
| M.Wt: | 209.67 |
| Formula: | C8H16ClNO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Swainsonine (Tridolgosir) hydrochloride is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine hydrochloride induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine hydrochloride shows anti-tumor activity[1][2][3].
In Vitro: Swainsonine hydrochloride (0-40 µM; 12 h) shows antiproliferative activity in U251 and LN444 cells[2].
Swainsonine hydrochloride (30 µM; 12 h) induces apoptosis and cell cycle arrest at G2/M phase, and decreases the expression of CyclinD1 and CDK4 protein levels, increases the expression of p16 protein level[2].
Swainsonine hydrochloride (30 µM; 12 h) reduces glioma cell migration and invasion[2].
In Vivo: Swainsonine hydrochloride (1 mg/kg; i.p.; twice daily for ten days) and cisplatin increases the anti-tumor efficacy in mouse[3].
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