Gly-Phe-β-naphthylamide
CAS No. : 21438-66-4
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| Cat. No. : | HY-W011063 |
| M.Wt: | 347.42 |
| Formula: | C21H21N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Gly-Phe-β-naphthylamide is a substrate of Cathepsin C (HY-P2922) and belongs to the lysosomal agonist. Gly-Phe-β-naphthylamide can freely pass through the cell membrane and organelle membrane. Gly-Phe-β-naphthylamide will be specifically hydrolyzed by Cathepsin C, ultimately leading to a permeability lysis when it enters the acidic compartment. Gly-Phe-β-naphthylamide can be used to study lysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C[1][2][3].
In Vitro:Gly-Phe-β-naphthylamide (0-200 μM, 0-16 h) respectively disruptes the function of lysosomes in isolated mouse pancreatic acinar cells and T lymphocytes[1][2].
Gly-Phe-β-naphthylamide (0-200, 0-200s) effectively alkalizes the acrosome and triggers calcium signals. Its osmotic perturbation function proves that the acrosome reaction is unrelated to osmotic perturbation[3].
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