1400W (Dihydrochloride)
CAS No. : 214358-33-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $88 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $308 | In-stock |
| 100mg | $528 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-18731 |
| M.Wt: | 250.17 |
| Formula: | C10H17Cl2N3 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation[1][2].
IC50 & Target:Ki: 2 µM (nNOS), 50 µM (eNOS)[1]
In Vitro:1400W (60 μM, 1 h) reduces NO, 3-NT and MDA production in primary adult microglia, and prevents neuronal cell apoptosis in cerebral cortex[2].
In Vivo:1400W (0.1-10 mg/kg, s.c., once time) inhibits the leakage of rats ileum, with an EC50 of 0.16 mg/kg[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- 1400W (Dihydrochloride)
- Cat. No.:
- HY-18731
- Quantity:
Your information is safe with us.