2BAct
CAS No. : 2143542-28-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $190 | In-stock |
| 10mg | $285 | In-stock |
| 25mg | $490 | In-stock |
| 50mg | $685 | In-stock |
| 100mg | $960 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-125021 |
| M.Wt: | 440.80 |
| Formula: | C19H16ClF3N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
2BAct is a highly selective, orally active, and CNS-penetrant eIF2B (eukaryotic initiation factor 2B) activator with an EC50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB trans-isomer (HY-12495)[1].
IC50 & Target:EC50: 33 nM (eIF2B)[1]
In Vitro:Primary fibroblast lysates from R191H embryos has lower GEF activity than WT lysates, and 2BAct enhances this activity threefold (EC50=7.3 nM)[1].
In Vivo:2BAct (300 μg 2BAct/g of meal; 21 weeks) normalizes body weight gain in VWM mice[1].
2BAct prevents the appearance of motor deficits, myelin loss and reactive gliosis in VWM mice[1].
2BAct stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response[1].
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