GeA-69
CAS No. : 2143475-98-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $42 | In-stock |
| 10mg | $78 | In-stock |
| 25mg | $155 | In-stock |
| 50mg | $250 | In-stock |
| 100mg | $360 | In-stock |
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| Cat. No. : | HY-108708 |
| M.Wt: | 300.35 |
| Formula: | C20H16N2O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
GeA-69 is a selective, allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2 (MD2), with a Kd value of 2.1 µM. GeA-69 involves in DNA damage repair mechanisms and prevents recruitment of PARP14 MD2 to sites of laser-induced DNA damage[1][2].
IC50 & Target:Kd: 2.1 µM (PARP14)[1]
In Vitro:GeA-69 (compound 1) (50 μM and 250 μM; pre-damage for 1 h or 0.5, 1, 2.5 min) engages PARP14 MD2 in intact cells and prevents its localisation to sites of DNA damage in U-2 OS cells[2].
GeA-69 (25 nM-250 μM; 72 h) exhibits moderate cytotoxicity among HeLa, U-2 OS and HEK293 cells and highly cell permeable with 2 % passing paracellular and 98 % transcellular over the membrane[2].
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