(S)-Willardiine
CAS No. : 21416-43-3
(Synonyms: (-)-Willardiine)
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $94 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $414 | In-stock |
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| Cat. No. : | HY-12499 |
| M.Wt: | 199.17 |
| Formula: | C7H9N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic) |
(S)-Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. IC50 value: 44.8 uM(EC50) [1] Target: AMPA/kainate receptor agonist in vitro: The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses [1]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% [2]. in vivo: In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists [3].
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