2'-O-Methylcytidine
CAS No. : 2140-72-9
| Size | Price | Stock |
|---|---|---|
| 1g | $19 | In-stock |
| 5g | $57 | In-stock |
| 10g | $113 | In-stock |
| 25g | $281 | In-stock |
| 100g | $755 | In-stock |
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| Cat. No. : | HY-W011834 |
| M.Wt: | 257.25 |
| Formula: | C10H15N3O5 |
| Purity: | >98 % |
| Solubility: | H2O : 58.33 mg/mL (ultrasonic) |
2'-O-Methylcytidine is an orally active 2'-substituted nucleoside as a inhibitor of HCV replication with antiviral activity. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate[1][2][3].
In Vitro:2'-O-Methylcytidine (0.01-100 μM, 24 h) inhibits HCV RNA replication with an IC50 value of 21 μM in HBI10A cells[1].
2'-O-Methylcytidine (2 μM, 23 h) yields very little triphosphate and suffers from extensive metabolism to species that are consistent with UTP and CTP in HBI10A cells[1].
In Vivo:2'-O-Methylcytidine (16.6 mg/kg, p.o., daily for 7 days) reduces the serum HCV RNA in chronically infected chimpanzees[3].
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