FX-11
CAS No. : 213971-34-7
(Synonyms: LDHA Inhibitor FX11)
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1550 | In-stock |
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| Cat. No. : | HY-16214 |
| M.Wt: | 350.41 |
| Formula: | C22H22O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
FX-11 is a potent, selective, reversible and competitive lactate dehydrogenase A (LDHA) inhibitor, with a Ki of 8 μM. FX-11 reduces ATP levels and induces oxidative stress, ROS production and cell death. FX-11 shows antitumor activity in lymphoma and pancreatic cancer xenografts[1][2][3].
IC50 & Target:IC50: 23.3 μM (LDHA in HeLa cell) [1].
In Vitro:FX-11 (9 μM, 24-48 h) shows activation of AMP kinase and phosphorylation of its substrate acetyl-CoA carboxylase[2].
FX-11 (0-100 μM, 72 h) inhibits cell proliferation in BxPc-3 and MIA PaCa-2 cells[3].
FX-11 inhibits glycolysis and alters cellular energy metabolism in P493 cells[2].
In Vivo:FX-11 (42 μg/mouse; IP, daily for 10-14 days) inhibits P493 tumor growth[2].
FX-11 (0-2 mg/kg, IP, daily, for 3 weeks) significantly delays tumor growth[3].
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