THAL-SNS-032
CAS No. : 2139287-33-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $175 | In-stock |
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| Cat. No. : | HY-123937 |
| M.Wt: | 869.02 |
| Formula: | C40H52N8O10S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1].
IC50 & Target:CDK9[1]
In Vitro: THAL-SNS-032 selectively induces degradation of CDK9[1].
THAL-SNS-032 diminishes elongating polymerase II[1].
THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1].
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