ZT55
CAS No. : 2138488-38-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $185 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $600 | In-stock |
| 50mg | $970 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-124727 |
| M.Wt: | 296.32 |
| Formula: | C17H16N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC50 value of 0.031 μM. ZT55 inhibits the proliferation of JAK2V617F-expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia[1].
In Vitro:ZT55 (0-100 μM; 48 h) inhibits the proliferation of JAK2V617F (+) HEL cells in a concentration-dependent manner (IC50=18.05 μM)[1].
ZT55 (12.5, 25, 50 μM; 24, 48, 72 h) inhibits the cell viability and induces apoptosis of HEL cells in a concentration- and time-dependent manner[1].
ZT55 (12.5, 25, 50 μM; 24 h) arrests HEL cells in the G2/M phase in a concentration-dependent manner[1].
In Vivo:ZT55 (100 mg/kg; p.o; once a day for 2 weeks) drastically attenuates the growth of subcutaneous HEL tumors in nude mice[1].
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