STING agonist-3
CAS No. : 2138299-29-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $700 | In-stock |
| 25mg | $1100 | In-stock |
| 50mg | $1850 | In-stock |
| 100mg | $2680 | In-stock |
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| Cat. No. : | HY-103665 |
| M.Wt: | 750.81 |
| Formula: | C37H42N12O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 41.67 mg/mL (ultrasonic) |
STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer[1]. In Vitro: STING agonist-3 exhibits a pEC50 value of 7.5 in activation of STING in cells, this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter[1]. STING agonist-3 exhibits a pIC50 value of 9.5 in FRET assay. This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING[1].
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