SPOP-IN-6b
CAS No. : 2136270-20-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $110 | In-stock |
| 5mg | $220 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $630 | In-stock |
| 50mg | $900 | In-stock |
| 100mg | $1240 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-122615 |
| M.Wt: | 500.59 |
| Formula: | C28H32N6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM (patent CN 107141287, SPOP-B-88)[1].
IC50 & Target: SPOP[1]
In Vitro: SPOP-IN-6b shows IC50s of 2-10.2 μM for A498, Caki-2, Ketr-3, 769-P, 0S-RC-2, and 786-0 cells[1].
SPOP-IN-6b (0.1-3.0 μM; 10 hours) can suppress SPOP activity, and then increase suppression cancer substrate protein PTEN and DUSP7 content[1].
In Vivo: SPOP-IN-6b (40-80 mg/kg; i.p.; daily; for 25 days) can slow down the growth of tumour by suppressing SPOP[1].
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