(S)-Indoximod
CAS No. : 21339-55-9
(Synonyms: 1-Methyl-L-tryptophan; (S)-NLG-8189)
| Size | Price | Stock |
|---|---|---|
| 5g | $83 | In-stock |
| 10g | $166 | In-stock |
| 25g | $412 | In-stock |
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| Cat. No. : | HY-N0707 |
| M.Wt: | 218.26 |
| Formula: | C12H14N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 4.81 mg/mL (ultrasonic;warming;adjust pH to 4 with HCl;heat to 60°C) |
(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (Ki: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease[1][2][3][4].
IC50 & Target:Indoleamine 2,3-Dioxygenase (IDO)[1]
In Vitro:(S)-Indoximod (750 μM, 24 h) reduces IDO activity in HEK293 cells transduced with human IDO1 gene[4].
(S)-Indoximod (0.5 mM, 48 h) makes the cells released from IFN-γ (100 ng/mL)-mediated G1 cell cycle arrest, and then promotes the apoptosis of hepatic stellate cells[6].
In Vivo:(S)-Indoximod (5 mg/day, i.p. for 3 weeks) reverses the Bacillus Calmette-Guerin (BCG)-induced neurotoxicity in mice[3].
(S)-Indoximod (200 mg/kg, oral gavage) shows delayed, lasts longer renoprotective effect than D isomer, and increases survival in the IRI rat model[4].
(S)-Indoximod (1-9 mg/kg, i.p.) reverses cognitive, anxiety, and depressive-like behavior in bile duct ligation (BDL) rats[5].
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