HSP27 inhibitor J2
CAS No. : 2133499-85-9
(Synonyms: J2)
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $600 | In-stock |
| 25mg | $1000 | In-stock |
| 50mg | $1600 | In-stock |
| 100mg | $2600 | In-stock |
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| Cat. No. : | HY-124653 |
| M.Wt: | 264.30 |
| Formula: | C13H12O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].
IC50 & Target:HSP27[2]
In Vitro:HSP27 inhibitor J2 (10 μM; 12 h) induces significant abnormal HSP27 dimer formation in NCI-H460[1].
HSP27 inhibitor J2 (10 μM; 24 h) increases 17-AAG-induced apoptosis in shCTRL cells[1].
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