Vildagliptin (dihydrate)
CAS No. : 2133364-01-7
(Synonyms: LAF237 (dihydrate); NVP-LAF 237 (dihydrate))
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| Cat. No. : | HY-14291A |
| M.Wt: | 339.43 |
| Formula: | C17H29N3O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity[1].
IC50 & Target: IC50: 3.5 nM (DPP-IV, in human Caco-2 cells)[1]
In Vitro: Vildagliptin promotes beta cell survival by inhibiting cell apoptosis. Vildagliptin also promotes cell proliferation[2].
In Vivo: Vildagliptin (35 mg/kg; once daily by oral gavage) increases plasma active GLP-1 levels in islets of db/db mice[2].
Vildagliptin (10 µmol/kg; orally) significantly decreases glucose excursions and stimulate insulin secretion in obese male Zucker rats[1].
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