L-Azetidine-2-carboxylic acid
CAS No. : 2133-34-8
| Size | Price | Stock |
|---|---|---|
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| 250mg | $12 | In-stock |
| 1g | $18 | In-stock |
| 5g | $66 | In-stock |
| 10g | $127 | In-stock |
| 25g | $316 | In-stock |
| 100g | $1172 | In-stock |
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| Cat. No. : | HY-W050044 |
| M.Wt: | 101.10 |
| Formula: | C4H7NO2 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : < 1 mg/mL (ultrasonic) |
L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated eIF2α levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects[1][2][3][4][5][6][7][8][9].
In Vitro:L-azetidine-2-carboxylic acid increases glycosylations of collagen in chick-embryo tendon cells[1].
L-azetidine-2-carboxylic acid (5 mM, 9 h) induces ATF6 cleavage and upregulates BiP expression and phosphorylated eIF2α levels in HeLa cells[2].
L-azetidine-2-carboxylic acid (1-10 mM) reduces L-[U-14-C]proline incorporation into hemoglobin (25, 58, and 72% for 1, 5, and 10 mM, , respectively) in rabbit reticulocytes[3].
L-azetidine-2-carboxylic acid (350 μg/egg, daily, 9 days) prevents expression of the chondrogenic phenotype in embryonated eggs of Gallus domesticus[4].
L-azetidine-2-carboxylic acid (0-2000 µM, 6-24 h) shows pro-inflammatory and pro-apoptotic effects in BV2 microglial cells[5].
In Vivo:L-azetidine-2-carboxylic acid (200-600 mg/kg, i.p., given on gestational days 7-12) exhibits teratogenic effects in hamster fetuses[6].
L-azetidine-2-carboxylic acid (300 mg/kg, i.p., on day 8 of pregnancy) exhibits teratogenic effects on the skeletal system in rats[7].
L-azetidine-2-carboxylic acid (300 mg/kg, i.p., single) causes disrupted dentinogenesis in rats and mice[8].
L-azetidine-2-carboxylic acid (200 mg/kg, twice daily for 2 days) retards lung growth and surfactant synthesis in fetal rats[9].
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