BIRT 377
CAS No. : 213211-10-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1550 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-110117 |
| M.Wt: | 442.13 |
| Formula: | C18H15BrCl2N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders[1].
IC50 & Target:Ki: 25.8 nM (LFA-1)[1]
In Vitro:BIRT 377 (20 μM, 6 h) inhibits the mRNA and protein expression of EMT-related markers ZEB2 and Vementin in HT-29 cell whem cocultured with LAD2 cell[2].
BIRT 377 (20 μM, 24 h) inhibits the cell migration of HT-29, when cocultured with LAD2[2].
In Vivo:BIRT 377 (3-10 mg/kg, po, once daily for 14 days) inhibits the production of human IgG in hPBMC-injected mouse models, with an effect comparable to that of anti-LFA-1 antibodies[3].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- BIRT 377
- Cat. No.:
- HY-110117
- Quantity:
Your information is safe with us.