5-Amino-8-hydroxyquinoline (dihydrochloride)
CAS No. : 21302-43-2
(Synonyms: 5A8HQ (dihydrochloride); 5AHQ (dihydrochloride))
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| Cat. No. : | HY-W001023A |
| M.Wt: | 233.09 |
| Formula: | C9H10Cl2N2O |
| Purity: | >98 % |
| Solubility: |
5-Amino-8-hydroxyquinoline (5A8HQ; 5AHQ) dihydrochloride is an orally active non-competitive 20S proteasome inhibitor. 5-Amino-8-hydroxyquinoline dihydrochloride can inhibit NF-κB activity and induce cancer cells death and shows low cytotoxicity towards normal hematopoietic cells. 5-Amino-8-hydroxyquinoline dihydrochloride can be used for the research of cancer, such as leukemia[1].
In Vivo:5-Amino-8-hydroxyquinoline dihydrochloride (50mg/kg; p.o.) inhibits tumor growth in the leukemia xenograft mouse models (MDAY-D2, K562, U937 cell lines)[1].
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