Purvalanol B
CAS No. : 212844-54-7
(Synonyms: NG 95)
| Size | Price | Stock |
|---|---|---|
| 5mg | $81 | In-stock |
| 10mg | $109 | In-stock |
| 25mg | $170 | In-stock |
| 50mg | $275 | In-stock |
| 100mg | $415 | In-stock |
| 200mg | $615 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-18299 |
| M.Wt: | 432.90 |
| Formula: | C20H25ClN6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 40 mg/mL |
Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum[1][1]. In Vitro: Purvalanol B binds to P. falciparum casein kinase 1 (CK1) from blood stage cell lysates and inhibits the growth a chloroquine-resistant strain of P. falciparum (FCR-3) with an IC50 of 7.07 μM[1].
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