PD 198306
CAS No. : 212631-61-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $240 | In-stock |
| 10mg | $360 | In-stock |
| 25mg | $609 | In-stock |
| 50mg | $840 | In-stock |
| 100mg | $1160 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-107620 |
| M.Wt: | 476.23 |
| Formula: | C18H16F3IN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
PD 198306 is a selective MAPK/ERK-kinase (MEK) inhibitor. PD 198306 results in an observable reduction in the Streptozocin induced increase in the level of active ERK1 and 2. Antihyperalgesic effects[1].
In Vitro: PD198306 significantly inhibits Tha-GFP replication by 25% at 10?μM, after 36?h[2].
PD198306 (5?μM) reduces Tha-Crimson replication significantly by 20% at 18?h but such a result could not be confirmed at 36?h[2].
In Vivo: Intrathecal administration of PD 198306 (1-30 μg per 10 μL) dose-dependently (1-30 μg) blocks static allodynia in both the streptozocin and the chronic constriction injury (CCI) models of neuropathic pain[1].
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