PD0166285 (dihydrochloride)
CAS No. : 212391-63-4
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| Cat. No. : | HY-13925A |
| M.Wt: | 585.35 |
| Formula: | C26H29Cl4N5O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PD0166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1[1].
IC50 & Target: IC50: 24 nM (WEE1), 72 nM (Myt1), 3.433 μM (Chk1)[1].
In Vitro: PD0166285 (0.5 μM) dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines[1].
PD0166285 sensitizes radiation-induced cell killing in p53 mutant HT29 cells and in the E6-transfected, p53-null ovarian cancer cell line PA-1 but to a lesser extent in p53 wild-type PA-1 cells. PD0166285 abrogates irradiation-induced G2 arrest and significantly increases mitotic cell populations[1].
PD0166285 acts as a radiosensitizer to sensitize cells to radiation-induced cell death with a sensitivity enhancement ratio of 1.23[1].
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