WNK-IN-11
CAS No. : 2123489-30-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $253 | In-stock |
| 10mg | $418 | In-stock |
| 50mg | $1045 | In-stock |
| 100mg | $1485 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-112094 |
| M.Wt: | 462.40 |
| Formula: | C21H21Cl2N5OS |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1. IC50 & Target: IC50: 4 nM (WNK1)[1]. In Vitro: WNK-IN-11 (compound 11) shows IC50<2 μM in the cellular OSR1 phosphorylation assay with reasonable aqueous solubility, albeit with still rather high microsomal clearance. WNK-IN-11 shows ATP noncompetitive inhibition. When tested against a panel of 440 human kinases at 10 μM concentration, 2500-fold above enzyme IC50 value, WNK-IN-11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and feline encephalitis virus-related (FER) kinase, neither of which are implicated for blood pressure regulation. This excellent selectivity profile is consistent with the predicted allosteric binding mode outside the highly conserved ATP-pocket[1].
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- Cat. No.:
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