UbcH5c-IN-1
CAS No. : 2123480-72-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $220 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $705 | In-stock |
| 50mg | $1125 | In-stock |
| 100mg | $1800 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-103046 |
| M.Wt: | 413.30 |
| Formula: | C22H21BrO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
UbcH5c-IN-1 (compound 6d) is a potent and selective small-molecule inhibitor of Ubiquitin-conjugating enzyme UbcH5c, with a Kd of 283 nM for E2 UbcH5c-IN-1 by covalent binding with Cys85. A promising lead compound for the development of new antirheumatoid arthritis (RA) agent[1]. IC50 & Target:Kd: 283 nM (E2 UbcH5c)[1]. In Vivo: UbcH5c-IN-1 (compound 6d) (5 and 20 mg/kg, p.o., daily, 10-20 days) treatment in Freund’s adjuvant (CFA)-induced adjuvant arthritis (AA) rat model results in appreciable decreases in the arthritis index score and hind paw swelling rate compared with those of the vehicle-treated AA model control group[1].
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