MRS 1477
CAS No. : 212200-21-0
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| Cat. No. : | HY-110145 |
| M.Wt: | 389.51 |
| Formula: | C21H27NO4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MRS 1477, a dihydropyridine derivative, is a positive allosteric modulator of TRPV1 in the presence of capsaicin. MRS 1477 itself does not induce apoptosis, but the co-existence of MRS 1477 and capsaicin can induce apoptosis[1][2].
In Vitro:MRS1477 evokes Ca2+ signals in MCF7 breast cancer cells, but not in primary breast epithelial cells[1].
MRS1477 (2 μM; 72 h) with capsaicine (10 μM) induces apoptosis and increases reactive oxygen species production and caspase activity[1].
MRS1477 (2 μM) increases capsaicin-evoked TRPV1-mediated current density levels[1].
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