GSK2850163
CAS No. : 2121989-91-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $460 | In-stock |
| 100mg | $740 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-U00459 |
| M.Wt: | 446.41 |
| Formula: | C24H29Cl2N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 67.5 mg/mL (ultrasonic);Ethanol : 50 mg/mL (ultrasonic) |
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. IC50 & Target: IC50: 20 nM (IRE1α kinase activity), 200 nM (IRE1α RNase activity)[1] In Vitro: GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. The increased autophosphorylation of IRE1α could be reduced in a dose-dependent manner by GSK2850163. Increasing concentrations of GSK2850163 are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163: Ron (IC50=4.4 μM) and FGFR1 V561M (IC50=17 μM)[1].
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