Dabigatran etexilate
CAS No. : 211915-06-9
(Synonyms: BIBR 1048)
| Size | Price | Stock |
|---|---|---|
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| 10mg | $84 | In-stock |
| 50mg | $119 | In-stock |
| 100mg | $158 | In-stock |
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| Cat. No. : | HY-10274 |
| M.Wt: | 627.73 |
| Formula: | C34H41N7O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation[1].
In Vivo:Dabigatran etexilate (BIBR 1048; oral; 10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys) has dose- and time-dependent anticoagulant effects and has maximum effects between 30 and 120 min after administration, respectively[1].
Dabigatran etexilate maximally and significantly prolongs partial thromboplastin time (aPTT) to 25.2, 38.4 and 78.3 s in 30 min after 10, 20 and 50 mg/kg oral doses, respectively[1].
Dabigatran etexilate maximally prolongs the aPTT to 34.3 s, 44.0 s, and 63.0 s, respectively, 2h after 1, 2.5 or 5 mg/kg doses in the monkey[1].
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