Dabigatran


CAS No. : 211914-51-1

(Synonyms: BIBR 953; BIBR 953ZW)

211914-51-1
Price and Availability of CAS No. : 211914-51-1
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5mg $106 In-stock
10mg $185 In-stock
25mg $370 In-stock
50mg $594 In-stock
100mg $950 In-stock
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Cat. No. : HY-10163
M.Wt: 471.51
Formula: C25H25N7O3
Purity: >98 %
Solubility: 0.1 M HCL : 12.5 mg/mL (ultrasonic);H2O : < 0.1 mg/mL;DMSO : < 1 mg/mL
Introduction of 211914-51-1 :

Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2]. IC50 & Target: Ki: 4.5 nM (thrombin)[1] In Vitro: Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively[1]. In Vivo: Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model[3].

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