| Size | Price | Stock |
|---|---|---|
| 5mg | $106 | In-stock |
| 10mg | $185 | In-stock |
| 25mg | $370 | In-stock |
| 50mg | $594 | In-stock |
| 100mg | $950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
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Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-10163 |
| M.Wt: | 471.51 |
| Formula: | C25H25N7O3 |
| Purity: | >98 % |
| Solubility: | 0.1 M HCL : 12.5 mg/mL (ultrasonic);H2O : < 0.1 mg/mL;DMSO : < 1 mg/mL |
Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM)[1][2]. IC50 & Target: Ki: 4.5 nM (thrombin)[1] In Vitro: Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively[1]. In Vivo: Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model[3].
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