Dabigatran (ethyl ester hydrochloride)
CAS No. : 211914-50-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $550 | In-stock |
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| Cat. No. : | HY-77521 |
| M.Wt: | 536.03 |
| Formula: | C27H30ClN7O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL;H2O : 5 mg/mL (ultrasonic) |
Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) with an IC50 value of 0.8 μM and a thrombin inhibitor. IC50 & Target: IC50: 0.8 μM (NQO2)[1] In Vitro: The Ki of dabigatran (ethyl ester hydrochloride) toward NQO2 is 0.9 μM and the IC50 is 0.8 μM. The ethyl ester group of dabigatran (ethyl ester hydrochloride) significantly extends the interaction surface especially with hydrophobic amino acids such as Ile 128 and Met 154. Dabigatran ethyl ester has higher affinity than Dabigatran to both thrombin and NQO2[1]. Dabigatran is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate[2]. In Vivo: Dabigatran (Ki=4.5 nM) could bind to human thrombin selectively, and reversibly to realize a strong and long-lasting anticoagulant effect[3].
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