Eniporide hydrochloride
CAS No. : 211813-86-4
(Synonyms: EMD-96785 hydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $84 | In-stock |
| 10mg | $144 | In-stock |
| 25mg | $288 | In-stock |
| 50mg | $504 | In-stock |
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| Cat. No. : | HY-106150B |
| M.Wt: | 356.83 |
| Formula: | C14H17ClN4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 55 mg/mL (ultrasonic);H2O : 4.17 mg/mL (ultrasonic;warming;heat to 60°C) |
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na+/H+ exchange inhibitor. IC50 & Target: Sodium Channel[1] In Vitro: There is no significant effects of the Na+/H+ exchange inhibitor eniporide on cardiac performance and high energy phosphate content in healthy pig hearts subjected to ischemia/reperfusion induced by crystalloid cardioplegic arrest[1]. In Vivo: In stage 1, the administration of 100 mg and 150 mg eniporide results in smaller infarct sizes, especially in the angioplasty group. In contrast, in stage 2 there is no difference in the enzymatic infarct size between the three groups. Overall there is no effect of eniporide on clinical outcome (death, cardiogenic shock, heart failure, life-threatening arrhythmias). However, there is a significant reduction of the incidence of heart failure in patients reperfused late (>4 h)[2].
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