Tebipenem pivoxil (hydrochloride)
CAS No. : 211558-19-9
(Synonyms: L084 (hydrochloride))
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| Cat. No. : | HY-B0396A |
| M.Wt: | 534.09 |
| Formula: | C22H32ClN3O6S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tebipenem pivoxil (L084) hydrochloride is an orally active antibiotic against a variety of pathogenic bacteria. Tebipenem pivoxil hydrochloride binds penicillin-binding protein (PBP), thereby inhibiting cell wall synthesis[1].
In Vitro: Tebipenem pivoxil hydrochloride (0-128 μg/mL, 18–24 h) displays excellent antibacterial activity against a variety of pathogenic bacteria[1].
In Vivo: Tebipenem pivoxil (L084) (0-4.00 g/kg; p.o.; once) hydrochloride shows minimal lethal dosage (MLD) of 4.00 g/kg and the maximum tolerance dosage (MTD) of 3.40 g/kg in mice[1].
Tebipenem pivoxil (50 and 100 mg/kg; p.o.; once) hydrochloride significantly protects the sepsis mice challenged with various pathogenic bacteria[1].
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